Barcelona slumped to a 1-0 home defeat by Rayo Vallecano which pushed leaders Real Madrid a step closer to the La Liga title.
PSG looked sluggish and apathetic as the Ligue 1 leaders slumped to a 3-0 defeat at Monaco, while Tammy Abraham scored twice in the Rome derby.
Tammy Abraham's penalty more than nine minutes into stoppage time ended Roma’s winless run as Jose Mourinho's scraped a 1-0 victory at 10-man Spezia in Serie A.
Barcelona were held 1-1 at home by Napoli in the first leg of their Europa League knockout stage playoff tie on Thursday.
Ahead of the 2021/22 Europa League knockout round play-offs, we bring you the state of play, upcoming fixtures and the schedule for the remainder of the tournament.
Olivier Giroud again showed why he can never be written off, scoring two late goals as AC Milan rallied to beat rivals Inter 2-1 and reignite Serie A title race.